Journal
PEDIATRIC BLOOD & CANCER
Volume 52, Issue 2, Pages 259-262Publisher
WILEY
DOI: 10.1002/pbc.21757
Keywords
clinical trial; immune thrombocytopenia; rituximab
Categories
Funding
- NCRR NIH HHS [M01 RR000070, M01-RR0000047, M01 RR002172, M01RR-001271, M01 RR000865, M01 RR000188, M01RR002172, M01RR000865, M01 RR001271, M01 RR000047, M01RR000188] Funding Source: Medline
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Background. We previously showed in a prospective Study that rituximab appears to be effective in some children and adolescents with severe chronic immune thrombocytopenia. Eleven of 36 patients achieved and maintained platelet counts Over 50,000/mm(3) within the first 12 weeks. These patients were followed for the next year. Methods. Platelet Count,; were monitored monthly and all subsequent bleeding manifestations and need for further treatment was noted. Results. Eight of the 11 initial responders maintained a platelet count over 150,000/mm(3) Without further treatment intervention. Three patients had a late relapse. One initial non-responder achieved a remission after 16 weeks, and two additional patients maintained platelet counts around 50,000/mm(3) without the need for further intervention. Conclusions. Rituximab resulted in sustained efficacy with platelet Counts of 50,000/mm(3) or higher in 11 of 36 patients (31%). Pediatr Blood Cancer 2009;52:259-262. (C) 2008 Wiley-Liss, Inc.
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