Journal
PEDIATRIC BLOOD & CANCER
Volume 53, Issue 1, Pages 120-124Publisher
WILEY
DOI: 10.1002/pbc.21955
Keywords
haploidentical stern cell transplantation; KIR-HLA mismatch; NK cells; pediatric solid tumors
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Funding
- Fundacion Inocente
- Spanish National Health Service [FIS CM-04/00011]
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Killer immunoglobulin-like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR-HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. Pediatr Blood Cancer 2009;53:120-124. (C) 2009 Wiley-Liss, Inc.
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