Journal
PEDIATRIC BLOOD & CANCER
Volume 50, Issue 5, Pages 1006-1012Publisher
WILEY
DOI: 10.1002/pbc.21336
Keywords
acute chest syndrome; cohort study; corticosteroids; sickle cell disease; transfusions
Categories
Funding
- Intramural NIH HHS [Z01 CL008070-04, Z99 HL999999, ZIA HL006014-02] Funding Source: Medline
- NCRR NIH HHS [K12RR01627] Funding Source: Medline
Ask authors/readers for more resources
Background. Acute chest syndrome (ACS) is a frequent cause of hospitalization and mortality in children with sickle cell disease. Transfusion is often required to prevent respiratory failure and treatment with dexamethasone may reduce the length of admission and the need for transfusions. We performed a retrospective cohort study to evaluate risk factors for readmission and prolonged hospitalization after different treatments for ACS. Procedure. We identified patients <22 years of age hospitalized with ACS at Johns Hopkins Hospital from January 1998 to April 2004 using the hospitals discharge database and by reviewing dictated summaries. Results. We identified 65 patients with 129 episodes of ACS (mean age 12.5 years, range 1.2-21.9 years). Thirty-nine episodes were treated with corticosteroids and 51 with transfusions. Patients were readmitted within 14 days after 23 episodes (18%). Readmission was strongly associated with report of an inhaler or nebulizer at home [odds ratio (OR) 6.0, P<0.05], diastolic BP at 48 hr (OR 1.8 per 10 mm increase, P<0.01), corticosteroids (OR 20, P<0.005), or transfusion (OR 0.03, P< 0.05). Treatment with corticosteroids alone (P<0.05) and older age (P<0.001) were associated with longer hospitalization. Conclusions. These results demonstrate a greatly elevated independent risk of readmission after ACS in children with asthma and after treatment with corticosteroids and a protective effect of transfusion. Although dexamethasone has documented efficacy for reducing the duration of ACS, the substantial risk of readmission for pain should limit its use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available