Journal
PEDIATRIC ALLERGY AND IMMUNOLOGY
Volume 19, Issue -, Pages 17-25Publisher
WILEY
DOI: 10.1111/j.1399-3038.2008.00764.x
Keywords
atopic eczema; filaggrin; food allergy; topical corticosteroids; calcineurin inhibitors
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Atopic eczema (AE) is a chronic inflammatory skin disease characterized by pruritus, dry skin and an ongoing course of exacerbations and remissions. AE is a common disorder in children with a worldwide cumulative prevalence of 15-20% in this age group. AE has a strong familial predisposition. While AE is a complex disease with multiple gene involvement, recent interest has focused on genes involved in skin barrier/epidermal differentiation and in immune response/host defense. Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed.
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