Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 206, Issue 2, Pages 98-101Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.prp.2009.06.010
Keywords
FABP-7; Breast cancer; Triple-negative breast cancer; Basal-like subtype
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Fatty acid binding protein-7 (FABP-7) is normally expressed in the mammary gland. The aim of this study was to clarify the phenotype of breast cancers with respect to the overexpression of FABP-7. Reverse transcription PCR (RT-PCR) analysis was carried out on 16 cases, including 4 ER(+)/HER2(-), 2 ER(+)/HER2(+), 3 ER(-)/HER2(+), and 5 ER(-)/HER2(-) samples, and 2 non-neoplastic mammary glands as control tissue. Breast cancers categorized as ER(-)/HER2(-) revealed a high cDNA level of FABP-7 as compared to other groups of breast cancer (p = 0.004). An immunohistochemical study carried out on 88 cases showed that FABP-7 overexpression had a strong relationship with triple-negative cases (45.8%, p = 0.001) and the basal-like subtype (37.5%, p = 0.001). Estrogen receptor (ER) and progesterone receptor (PgR) expressions had reverse correlation with FABP-7 overexpression (p = 0.003, p < 0.0001), but no significant associations can be identified between human epidermal growth factor receptor-2 (HER2) and FABP-7 (p = 0.219). In conclusion, this study is the first to demonstrate overexpression of FABP-7 in triple-negative breast cancers [ER(-), PgR(-)/HER2(-)], especially in basal-like breast cancer, and to give a probable interpretation of the high histological grade and poor prognosis of basal-like breast cancer. (C) 2009 Elsevier GmbH. All rights reserved.
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