Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 19, Issue 4, Pages 611-617Publisher
SPRINGER
DOI: 10.1007/s12253-013-9663-8
Keywords
Klotho; Insulin/IGF1 axis; Autophagy; Wnt signaling; ROS
Ask authors/readers for more resources
The klotho gene is a classical aging suppressor gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of several types of human cancers. Klotho functions as a tumor suppressor by inhibiting insulin/IGF1, p53/p21, and Wnt signaling. Silencing klotho gene expression is mainly mediated through promoter hypermethylation and histone deacetylation in cancer. Klotho has been proposed to take part in cell proliferation, survival, autophagy, and resistance to anti-cancer therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available