Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 19, Issue 2, Pages 149-154Publisher
SPRINGER
DOI: 10.1007/s12253-012-9600-2
Keywords
Calreticulin; Endoplasmic reticulum; Cancer; Malignant progression; Invasion; Metastasis
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Calreticulin (CRT) as a multi-functional endoplasmic reticulum protein is involved in a spectrum of cellular processes which ranges from calcium homeostasis and chaperoning to cell adhesion and finally malignant formation and progression. Previous studies have shown a contributing role for CRT in a range of different cancers. This present review will focus on the possible roles of CRT in the progression of malignant proliferation and the mechanisms involved in its contribution to cancer invasion.
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