Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 17, Issue 4, Pages 791-800Publisher
SPRINGER
DOI: 10.1007/s12253-011-9433-4
Keywords
Necrosis; Necroptosis; Programmed cell death; RIPK1; RIPK3; TNF; Death receptor
Funding
- [ETT 016/2008]
Ask authors/readers for more resources
Programmed cell death is a key component of tissue homeostasis, normal development and wide variety of diseases. Conventional view refers to programmed cell death form as caspase-mediated apoptosis while necrosis is considered as an accidental and unwanted cell demise, carried out in a non-regulated manner and caused by extreme conditions. However, accumulating evidences indicate that necrotic cell death can also be a regulated process. The term necroptosis has been introduced to describe a cell death receptor-induced, caspase-independent, highly regulated type of programmed cell death process with morphological resemblance of necrosis. Necroptosis recently has been found to contribute to a wide range of pathologic cell death forms including ischemic brain injury, neurodegenerative diseases and viral infection, therefore a better understanding of the necroptotic signaling machinery has clinical relevance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available