Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 15, Issue 3, Pages 487-493Publisher
SPRINGER
DOI: 10.1007/s12253-008-9143-8
Keywords
Esophageal squamous cell carcinoma; Beclin-1; HIF-1 alpha; Immunohistochemistry; Clinicopathological factors; Survival
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In the present study, we examined the relationship between Beclin-1 expression and HIF-1 alpha expression in esophageal squamous cell carcinoma(ESCC). There was a loss of Beclin-1 protein expression in 33% of ESCCs. Beclin-1 expression significantly correlated with depth of invasion, lymph node metastasis and clinical stage. Among the 54 patients, The survival rate of the Beclin-1-positive group was better than that of the Beclin-1-negative group. Twenty-five of the 54 (46%) tumor specimens showed high levels of HIF-1 alpha immunoreactivity. Beclin-1 expression was associated with HIF-1 alpha expression. The survival rate of patients with Beclin-1-positive and HIF-1 alpha-low tumors was significantly higher than that of the other groups. These results suggest that Beclin-1 and HIF-1 alpha expression are important determinants of survival in ESCCs.
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