Journal
TRANSPLANT INTERNATIONAL
Volume 28, Issue 4, Pages 429-436Publisher
WILEY-BLACKWELL
DOI: 10.1111/tri.12510
Keywords
chronic kidney disease; dialysis; infant; kidney transplantation; outcome
Categories
Funding
- Hannover Medical School
Ask authors/readers for more resources
Renal replacement therapy has become available for the majority of patients suffering from severe congenital chronic kidney disease (CKD). Data on the long-term neurocognitive outcome and the impact of early kidney transplantation (KTx) in this setting is unclear. Neurocognitive outcomes in 15 patients (11 male) with isolated congenital CKD (stage 3-5) requiring KTx at a mean age of 2.8 +/- 1.3 were assessed at a mean age of 8.3 +/- 1.4years. Patients underwent neurological examination and testing for neuromotor and neurocognitive function using three independent tests. Pre-emptive KTx was performed in six patients, and nine patients were dialyzed prior to KTx for a mean period of 11.1 +/- 8.6months. Neuromotor function was abnormal in 8/15 patients. HAWIK-III showed a global intelligence quotient (IQ) of 93.5 +/- 11.4 (P=0.05) due to a significantly reduced performance IQ of 89.1 +/- 11.3 (P<0.01). In three patients, the global IQ was clinically significantly reduced by >1 SD to <85. In patients with neuromotor dysfunction, performance IQ was lower than in patients with normal neuromotor function (83.8 +/- 10.2 vs. 96.2 +/- 9.0, P=0.04). Time on dialysis was inversely correlated to verbal IQ (r=0.78, P=0.02). Pre-emptive KTx and duration of dialysis treatment <3months was associated with superior neurocognitive outcome. Early (pre-emptive) KTx results in superior long-term neurocognitive outcome in children with severe congenital CKD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available