Journal
TRANSPLANT IMMUNOLOGY
Volume 33, Issue 2, Pages 58-62Publisher
ELSEVIER
DOI: 10.1016/j.trim.2015.08.002
Keywords
Antibody elution; Antibody-mediated rejection; Liver biopsy
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The current literature suggests that anti-HLA donor-specific antibodies (DSA) may have deleterious effects on liver grafts but there is no proof that they are directly involved in the graft lesions. We report the case of a donor HLA-sensitized patient who needed a second graft 6 months after the first transplantation owing to a progressive cholestatic disease that we could finally attribute to antibody-mediated rejection (AMR). We describe the longitudinal evolution of graft function, tissue histology, serum DSA and, for the first time, intra-graft DSA after elution from biopsies. (C) 2015 Elsevier B.V. All rights reserved.
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