Journal
TRANSLATIONAL RESEARCH
Volume 165, Issue 1, Pages 177-199Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2014.05.012
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Funding
- National Institutes of Health [NS060735, DE021804]
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Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.
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