Journal
PATHOBIOLOGY
Volume 80, Issue 4, Pages 203-210Publisher
KARGER
DOI: 10.1159/000347059
Keywords
Tendon injury; Tissue regeneration; Bioscaffolds; Growth factor, cell and gene therapies
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Funding
- German Research Foundation (Deutsche Forschungsgemeinschaft) within the Collaborative Research Center [SFB 599, HO 2058/4-1]
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The repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor-and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering. Copyright (C) 2013 S. Karger AG, Basel
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