Journal
PATHOBIOLOGY
Volume 75, Issue 2, Pages 75-84Publisher
KARGER
DOI: 10.1159/000123845
Keywords
breast cancer; stem cell; targeted therapy; aldehyde dehydrogenase
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Funding
- NCI NIH HHS [R01 CA129765-02, R01 CA129765] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA129765] Funding Source: NIH RePORTER
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There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular sub-component that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative. Copyright (c) 2008 S. Karger AG, Basel.
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