Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 31, Issue 1, Pages 134-142Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201300302
Keywords
positron emission tomography; metal oxide nanoparticles; labeled TiO2; proton activation
Funding
- 7th Framework Program through the HINAMOX Project [NMP4-SL-2009-228825, QNANO SP4-Capacities-2010-262163]
- Nanosolutions Project [NMP-2012 309329]
- Departamento de Industria, Comercio y Turismo of the Basque Government
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A simple and straightforward method is presented for the direct proton beam activation of O-18-enriched titanium dioxide nanoparticles (TiO2 NPs) via the O-18(p,n)F-18 nuclear reaction in order to assess the biological fate of the NPs using positron emission tomography (PET). The radiolabeling of the NPs does not alter their morphological properties as demonstrated by transmission electron microscopy and dynamic light scattering measurements. The simultaneous formation of other radioisotopes by activation of the titanium atom, i.e., V-48, V-47, Sc-44g, has been investigated using high-resolution gamma spectrometry and PET. The labeling of TiO2 NPs with radioactive F-18 atoms makes it possible to perform short-term in vivo biodistribution studies of the metal oxide NPs in rats after intravenous and oral administration using PET. The accumulation of NPs in different organs could be quantified during almost 8 h after administration.
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