Journal
PARKINSONISM & RELATED DISORDERS
Volume 64, Issue -, Pages 20-28Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2018.09.011
Keywords
Parkinson disease; Biomarkers; Diagnosis; Preclinical; Prodromal; Neuroprotective; Disease-modifying
Categories
Funding
- Parkinson Disease Research, Education, and Clinical Center of the Corporal Michael J. Crescenz VA Medical Center
Ask authors/readers for more resources
Given the increasing recognition that neurodegeneration begins decades before the appearance of motor symptoms of Parkinson disease (PD), recent attention has turned to methods of preclinical or prodromal diagnosis. Accurate preclinical diagnosis of individuals at high risk of developing manifest motor PD can improve clinical counseling as well as provide an enriched cohort for studies of possible disease-modifying therapies. In this review article, the authors synthesize the myriad clinical, radiographic, and biochemical signatures of preclinical PD, with an emphasis on biomarkers that may provide accurate population screening for the disease. As individual biomarkers have relatively lowsensitivity and specificity, any population-based approach to preclinical diagnosis will likely combine multiple biomarkers to improve both negative and positive predictive value.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available