The impact of non-motor symptoms on the Health-Related Quality of Life of Parkinson's disease patients from Southwest China

Background: The impact of non-motor symptoms (NMS) on the Health-Related Quality of Life (HRQoL) of patients with Parkinson's disease (PD) in the Chinese population are largely unknown. Objectives: To study the impact of NMS on the HRQoL in Chinese PD patients. Methods: A total of 693 PD patients from Southwest China were included in the study. NMS of patients were evaluated by non-motor symptoms scale (NMSS) and Parkinson's disease questionnaire-39 item version (PDQ-39) was used to evaluate the HRQoL of PD. Results: The mean total score of NMSS was 37.2 +/- 33.0 and the most prevalent NMS domain was sleep/fatigue (79.8%). There was a significant strong positive correlation between total NMSS score (r(s) = 0.71, P < 0.01), sleep/fatigue domain (r(s) = 0.60, P < 0.01) and PDQ-39 SI. Mood/apathy (r(s) = 0.55, P < 0.01), attention/memory (r(s) = 0.42, P < 0.01), gastrointestinal (r(s) = 0.44, P < 0.01) and Miscellany domains (r(s) = 0.46, P < 0.01) moderately correlated with PDQ-39 SI. A strong correlation was found between PDQ-39 SI (r(s) = 0.71, P < 0.01), emotional well-being (r(s) = 0.62, P < 0.01), cognitions (r(s) = 0.62, P < 0.01), and the total score of NMSS. Moderate correlation was found between mobility (r(s) = 0.45, P < 0.01), activities of daily living (r(s) = 0.43, P < 0.01), stigma (r(s) = 0.42, P < 0.01), communication (r(s) = 0.47, P < 0.01), bodily discomfort (r(s) = 0.46, P < 0.01) and the total score of NMSS. Female, H-Y stage, UPDRS-III and NMSS total score were the potential determinants of worse HRQoL of PD patients. Conclusions: NMS have close association with various aspects of the HRQoL. Severe NMS may be related to dramatic decline of the HRQoL of PD patients. (C) 2013 Elsevier Ltd. All rights reserved.