Journal
PARKINSONISM & RELATED DISORDERS
Volume 18, Issue 5, Pages 645-648Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2012.03.006
Keywords
PKD; Epilepsy; Focal EEG changes; ICCA; Genetics
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Funding
- Prinses Beatrix Foundation [WAR08-07]
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Paroxysmal kinesigenic dyskinesia (PKD) is characterized by involuntary dystonia and/or chorea triggered by a sudden movement. Cases are usually familial with an autosomal dominant inheritance. Hypotheses regarding the pathogenesis of PKD focus on the controversy whether PKD has a cortical or non-cortical origin. A combined familial trait of PKD and benign familial infantile seizures has been reported as the infantile convulsions and paroxysmal choreoathetosis (ICCA) syndrome. Here, we report a family diagnosed with ICCA syndrome with an Arg217STOP mutation. The index patient showed interictal EEG focal changes compatible with paroxysmal dystonic movements of his contralateral leg. This might support cortical involvement in PKD. (C) 2012 Elsevier Ltd. All rights reser ved.
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