Journal
PARKINSONISM & RELATED DISORDERS
Volume 16, Issue 8, Pages 498-502Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2010.05.006
Keywords
Corticobasal syndrome; Parkinson's disease; Corpus callosum; Diffusion tensor imaging
Categories
Funding
- Center of Advanced Imaging Magdeburg (CAI, BMBF) [01G00202, 01G00504]
Ask authors/readers for more resources
Differential diagnosis between patients with Corticobasal syndrome (CBS) and Parkinson's disease (PD) may be confusing, particularly in early disease stages. However, in contrast to PD, CBS shows a widespread cortical atrophy that suggests an involvement of the corpus callosum (CC). To test this hypothesis, we used diffusion tensor imaging (DTI) with a 1.5T scanner to compare 14 CBS patients, 14 PD patients, and an age-matched control group. The mean diffusivity (MD) and fractional anisotropy (FA) were determined in the whole CC and in five subdivisions. Group comparisons were performed using the Mann Whitney U-test. We found a significantly increased MD and decreased FA in CBS patients compared to PD, particularly in the posterior truncus. No differences were found between PD patients and controls. A receiver-operating characteristics (ROC) analysis shows that the MD is particularly useful for discriminating between the two neurodegenerative diseases. Our data suggest that abnormal CC diffusivity in CBS reflects an atrophy and degraded transcallosal connectivity, making the CC a potential target to differentiate CBS from PD patients. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available