Journal
PARKINSONISM & RELATED DISORDERS
Volume 14, Issue 4, Pages 309-313Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2007.09.005
Keywords
Parkinson's disease; cdk5; E2F-1; cell cycle
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The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD. (c) 2007 Elsevier Ltd. All rights reserved.
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