Journal
PARASITOLOGY RESEARCH
Volume 109, Issue 6, Pages 1501-1507Publisher
SPRINGER
DOI: 10.1007/s00436-011-2670-3
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Funding
- National Science and Technology Pillar Program of China [2009BAI78B06]
- Jiangsu Department of Health [X200912]
- Jiangsu Provincial Scientific Foundation of Preventive Medicine [Y201031]
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Praziquantel, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost, is virtually the only drug of choice for treatment of human schistosomiasis. Treatment of schistosomiasis has shown great advances with the introduction of the drug into the therapeutic arsenal in areas that are endemic for the parasite. However, the drug presents various efficacies against different developmental stages of schistosomes, appearing an oddity intermitted mode. The present review article reviews the effects and mechanism of action of praziquantel against schistosomes briefly and suggests the research on this oddity phenomenon.
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