Journal
PARASITOLOGY RESEARCH
Volume 107, Issue 4, Pages 889-899Publisher
SPRINGER
DOI: 10.1007/s00436-010-1946-3
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Funding
- National Natural Science Foundation of China [30901068]
- Science and Technology Commission of Shanghai Municipality of China [10410703400]
- Shanghai Talent Developing Foundation of China [2009032]
- Basic Foundation for Scientific Research of State-level Public Welfare Institutes of China [2008JB18, 2009JB08]
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Small non-coding RNAs including microRNAs and small interfering RNAs play important roles in many biological processes of many organisms. Argonaute proteins serve as a key component of the RNA-induced silencing complex for mediating miRNA/siRNA functions. In the present study, we systematically investigated Argonaute proteins in Schistosoma japonicum by using bioinformatics in combination with 5'- and 3'-Rapid Amplification of cDNA ends techniques and thus obtained three full-length cDNAs encoding Argonaute proteins, named as SjAgo1, SjAgo2, and SjAgo3, respectively. Additionally, SjAgo1/2/3 were differentially expressed in different developmental stages of schistosomes as determined by real-time RT-PCR and Western blot. Taken together, our preliminary results suggested that SjAgo1/2/3 may control gene expression during the life cycle of S. japonicum and therefore may regulate schistosome development and other biological processes.
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