Journal
PARASITOLOGY RESEARCH
Volume 106, Issue 5, Pages 1245-1248Publisher
SPRINGER
DOI: 10.1007/s00436-010-1771-8
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Funding
- FAPESP [06/57626-5]
- Conselho Nacional de Pesquisa e Desenvolvimento [473405/2008-3, 477422/2009-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [06/57626-5] Funding Source: FAPESP
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In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.
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