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Sand flies, Leishmania, and transcriptome-borne solutions

Journal

PARASITOLOGY INTERNATIONAL
Volume 58, Issue 1, Pages 1-5

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2008.07.004

Keywords

Saliva; Midgut; Vector-based vaccine; Transmission-blocking vaccine; Salivary gland

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Funding

  1. Intramural Research Program of the Division of Intramural Research
  2. National Institute of Allergy and Infectious Diseases
  3. National Institutes of Health
  4. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000932] Funding Source: NIH RePORTER

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Sand fly-parasite and sand fly-host interactions play an important role in the transmission of leishmaniasis. Vector Molecules relevant for such interactions include midgut and salivary proteins. These potential targets for interruption of propagation of Leishmania parasites have been poorly characterized. Transcriptomic analysis has proven to be an effective tool for identification of new sand fly molecules, providing exciting new insights into vector-based control strategies against leishmaniasis. Published by Elsevier Ireland Ltd.

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