Journal
PARASITOLOGY
Volume 136, Issue 12, Pages 1415-1426Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182009990916
Keywords
Theileria; cell biology; CD8 T cell; antigenic diversity; immunodominance; vaccination
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Funding
- Wellcome Trust [075820]
- BBSRC [BBS/E/D/05201236] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/05201236] Funding Source: researchfish
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The pathogenic Theileria species Theileria parva and T. annulata infect bovine leukocytes and erythrocytes causing acute, often fatal lymphoproliferative diseases in cattle. The parasites are of interest not only because of their economic importance as pathogens, but also because of their unique ability to transform the leukocytes they infect. The latter property allows parasitized leukocytes to be cultured as continuously growing cell lines in vitro, thus providing all amenable in vitro system to study the parasite/host cell relationship and parasite-specific Cellular immune responses. This paper summarizes important advances in knowledge of the immunobiology of these parasites over the last 40 years, focusing particularly on areas of relevance to vaccination.
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