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Radiation-attenuated schistosome vaccination - a brief historical perspective

Journal

PARASITOLOGY
Volume 136, Issue 12, Pages 1621-1632

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182009005848

Keywords

schistosomiasis; radiation attenuation; membrane antigens; secreted antigens; vaccine development

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The high level of protection which can be induced by vaccination of a range of hosts, from rodents to primates, with live radiation-attenuated schistosome larvae offers great promise for development of a human schistosome vaccine. Studies of the irradiated vaccine models benefitted from significant funding during the 1970-90s and much was learned concerning the inducers, targets and mechanisms of immunity. Less progress was made in definition of the protective antigens involved. The application of new techniques for identifying membrane and secreted antigens has recently provided new vaccine candidates and a new impetus for schistosome vaccine development. This article is intended as an overview of some of the main lessons learned from the studies of the irradiated vaccines as a backdrop to renewed interest in schistosome vaccine development.

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