Journal
PARASITE
Volume 18, Issue 2, Pages 121-126Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/2011182121
Keywords
Pneumocystis jirovecii; colonization; chronic pulmonary disease
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Funding
- Consejeria de Salud Junta de Andalucia [PI-0391/07]
- Ministerio de Ciencia e Innovacion [PI-080983]
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Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P jirovecii colonization has been found in patients with chronic pulmonary diseases it has been suggested that P jirovecii may play a role in the physiopathology and progression of those diseases. In this report we revise P jirovecii colonization in different chronic pulmonary diseases such us, chronic obstructive pulmonary disease, interstitial lung diseases, cystic fibrosis and lung cancer.
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