Journal
PARASITE
Volume 16, Issue 3, Pages 227-230Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/2009163227
Keywords
leishmaniasis; vaccine; hamster
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Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions.
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