Journal
PARASITE
Volume 15, Issue 3, Pages 515-521Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/2008153515
Keywords
P.falciparum; malaria; pregnancy; vaccine
Categories
Funding
- Institut of Applied Medicine and Epidemiology (IMEA) [Grant 5974 tui 90]
- French National Agency for Research [Grant ANR-05-MIME-009-01]
- EU/FP7 [Grant 200889]
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The consequences of pregnancy-associated malaria on pregnant women (anaemia), their babies (birth weight reduction), and infants (increased morbidity and mortality) are well documented. Field observations during the lost decade have underlined the key role of the interactions between P. falciparum variable surface antigens expressed on infected erythrocytes and a novel receptor: chondroitin sulfate A (CSA) for the placental sequestration of infected erythrocytes. Identification of a distinct P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant, VAR2CSA, as the dominant variant surface antigen and as a clinically important target for protective immune response to pregnancy-associated malaria has rased hope for developing a new preventive strategy based on inducing these immune responses by vaccination. However, despite particular structure and interclonal conservation of VAR2CSA among other PfEMP1, significant challenges still exist concerning the development of a VAR2CSA-based vaccine with profound efficacy.
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