Journal
PARASITE
Volume 15, Issue 3, Pages 197-205Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/2008153197
Keywords
Toxoplasma gondii; Plasmodium falciparum; Apicomplexa; adhesin; microneme; actin; myosin; proteases
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Funding
- Swiss National Foundation [FN 3100A0 - 102255/DS, 3100A0-116722/DS]
- LSHP-CT-2004-503578
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Gliding motility is an essential and fascinating apicomplexan-typical adaptation to an intracellular lifestyle. Apicomplexan parasites rely on gliding motility for their migration across biological barriers and for host cell invasion and egress. This unusual substrate-dependent mode of locomotion involves the concerted action of secretary adhesins, a myosin motor, factors regulating actin dynamics and proteases. During invasion, complexes of soluble and transmembrane micronemes proteins (MICs) and rhoptry neck proteins (RONs) are discharged to the apical pole of the parasite, some protein acts as adhesins and bind to host cell receptors whereas others are involved in the moving junction formation. These complexes redistribute towards the posterior pole of the parasite via a physical connection to the parasite actomyosin system and are eventually released from the parasite surface by the action of parasite proteases.
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