Journal
PARASITE IMMUNOLOGY
Volume 34, Issue 8-9, Pages 430-439Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-3024.2012.01377.x
Keywords
BMDCs; CD4+CD25+regulatory T cells; IFN-; Schistosoma japonicum; Sj16
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Funding
- National Basic Research Program of China (973 Program) [2007CB513102]
- National Important Sci-tech Special Projects [2008ZX10004-011]
- National Science Foundation of China [30972574, 81000743]
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Various proteins are expressed during different stages of schistosome development that are essential for cercarial penetration of vertebrate skin and evasion of host immune response. CD4+CD25+ regulatory T cells are important in modulating immune responses towards helminth infections. Schistosoma japonicum protein Sj16 present in the secretions of schistosomula has been shown to have anti-inflammatory effects; however, it is uncertain whether Sj16 can induce CD4+CD25+ regulatory T cells to participate in the regulation of early infection. In this study, we demonstrate a relationship between recombinant Sj16 (rSj16) and the induction of CD4+CD25+ Foxp3+ regulatory T cells. An increase in CD4+CD25+ T cells was observed both in splenic cells from mice injected with rSj16 and the cells pretreated with rSj16, respectively. The induced CD4+CD25+ T cells suppressed CD4+CD25- T-cell proliferation; furthermore, IFN-? and IL-10 released from rSj16-stimulated cells contribute to this suppression. Additionally, rSj16-treated bone marrow dendritic cells (BMDCs) demonstrate an immature phenotype and play a role in the conversion of CD4+CD25- T cells into suppressive CD4+CD25+ regulatory T cells. Our study identified a new CD4+CD25+ T-cell population that induced by rSj16 and suggests that an IFN-?-biased microenvironment during early infection of schistosome may favour the establishment of infection.
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