Journal
PARASITE IMMUNOLOGY
Volume 31, Issue 11, Pages 697-705Publisher
WILEY
DOI: 10.1111/j.1365-3024.2009.01128.x
Keywords
burden; epilepsy; helminths; pathogenesis; seizures
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Funding
- Rotary International Foundation
- The Wellcome Trust, UK
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P>Both helminthiases and epilepsy occur globally, and are particularly prevalent in developing regions of the world. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. We review the available literature on the global burden of helminths, and the epidemiological evidence linking helminths to epilepsy. We discuss possible routes that helminths affect the central nervous system (CNS) of humans and the immunological response to helminth infection in the CNS, looking at possible mechanisms of epileptogenesis. Finally, we discuss the current gaps in knowledge about the interaction between helminths and epilepsy.
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