Journal
PANCREATOLOGY
Volume 8, Issue 4-5, Pages 462-469Publisher
ELSEVIER
DOI: 10.1159/000151537
Keywords
pancreatic cancer; pancreatic plasticity; signal transduction; stem cell; tumor stroma
Categories
Funding
- Instituto de Salud Carlos III [PI05/2738, CP04/00292, PI05/1912]
- Departament de Sanitat de la Generalitat de Catalunya
- Plan Nacional de I+D
- Ministerio de Educacion y Ciencia [SAF2005-00704, SAF2004-01137, SAF2007-60860]
- Fundacio La Marato TV3 [051110]
- Generalitat de Catalunya [2005SGR00729]
- [LSHB-CT-2006-018771 MOLDIAG-PaCa]
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Pancreatic cancer has a very poor prognosis, in part due to its diagnosis at late stages of the disease and to limited response to chemotherapy and radiotherapy. The vast majority of pancreatic cancers are classified as pancreatic ductal adenocarcinomas (PDACs). Despite advances in knowledge on the cellular origin of PDAC or the involvement of signal transduction pathways therein, many questions remain unanswered. In this review, we summarize recent findings and current hypotheses regarding these two questions. Since pancreatitis is a risk factor for human PDAC, and the latter proceeds with an intense fibrotic reaction, we also analyze the role of the stroma in PDAC progression. An improved understanding of these key aspects for PDAC ontogeny will open new avenues for tumor prevention, early detection, and improved therapy. Copyright (C) 2008 S. Karger AG, Basel and IAP.
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