Changing incidence of pancreatic neoplasms - A 16-year review of statewide tumor registry

Objectives: Although most pancreatic neoplasms are adenocarcinoma, there are many other histological types, some of which may be increasing in frequency. To better de. ne these trends, we reviewed 16 years of data from a statewide tumor registry. Methods: Using the State of Michigan tumor registry, all patients with primary pancreatic cancers from 1986 to 2002 were identified, and patients were excluded if there were insufficient data or the histological subtype was not clearly defined in the literature. Results: There were 17,610 pancreatic neoplasms identified, and 2425 were excluded, leaving a final population of 15,185. Twenty five types of primary pancreatic neoplasms were identified. The most common were adenocarcinoma, mucinous cystadenocarcinoma, nonfunctional neuroendocrine, adenosquamous, anaplastic, intraductal papillary mucinous, and acinar cell (8.37, 0.43, 0.18, 0.05, 0.04, 0.04, and 0.02 per 100,000 per year, respectively). The mean age at presentation was similar for tumor types, 69.2 years old, with the exception of endocrine neoplasms occurring at a younger age, 58.5 years old (P < 0.0005). There was a significant change in the incidence of nonfunctional neuroendocrine neoplasms, greater than 2-fold increase (P = 0.0003). Conclusions: The incidence of most pancreatic neoplasms has changed a little; however, nonfunctional neuroendocrine neoplasms increased greater than 2- fold. The etiology of this change is unclear.