Journal
TRAFFIC
Volume 16, Issue 12, Pages 1210-1238Publisher
WILEY
DOI: 10.1111/tra.12335
Keywords
adaptin; adaptor; dynamin; endocytosis; sorting signals; trans-Golgi network
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Funding
- Wellcome Trust [086598]
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The purification of coated vesicles and the discovery of clathrin by Bar-bara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin-mediated trafficking is regulated and how the machinery evolved.
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