Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects

Background: Oxidative stress and imbalances in trace element status have been proposed as emerging risk factors for coronary heart disease (CHD). The present study aimed to determine serum concentrations of zinc (Zn), copper (Cu) and their ratio, as well as activities of superoxide dismutase (SOD) enzyme following supplementation with curcuminoids in obese subjects. Methods: 30 obese subjects were randomly allocated to receive curcuminoids (1 g/day; co-supplemented with piperine (10 mg/day) to improve bioavailability of curcuminoids) or matching placebo for 4 weeks, followed by a 2-week wash-out period and subsequent crossing over to the alternate treatment. Serum levels of Cu, Zn, Zn/Cu, Cu/Zn, and SOD activities were determined 4 times for each subject i.e., at the start and end of treatment with curcuminoids and placebo. Results: Supplementations with curcuminoids was associated with a significant increase in serum Zn/Cu and a reduction in Cu! Zn. However, no significant alteration was observed in serum concentrations of Zn and Cu, nor in SOD activities. Conclusion: Short-term supplementation with curcuminoids improves serum Zn/Cu ratio. This effect may justify part of the reported cardioprotective effects of curcuminoids.