Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 68, Issue -, Pages 28-36Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2015.02.009
Keywords
Dissociable compound; Gradient elution; High-performance liquid chromatography; Isocratic elution; Lipophilicity; Mobile phase; Mobile-phase additive; n-octanol/water partition coefficient; Retention-time correction; Stationary phase
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Funding
- National Natural Science Foundation of China [21275069, 90913012, 20575027]
- National Basic Research Program of China (973 Program) [2011CB911003, 2009CB421601]
- National Science Funds for Creative Research Groups [21121091]
- Analysis & Test Fund of Nanjing University
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Lipophilicity, quantified by the logarithm of the n-octanol/water partition coefficient (logP) or the distribution coefficient (logD), is a crucial parameter for modelling biological partition or distribution. As a maintream experimental method for lipophilicity measurement, reversed-phase high performance liquid chromatography (RP-HPLC) has attracted great interest and the attention of researchers throughout the world for its advantages including speed, reproducibility, insensitivity to impurities and degradation products, broad dynamic range, on-line detection, and reduced handling and sizes of samples. This review focuses on recent developments in lipophilicity measurement by RP-HPLC, both theoretical and experimental (mainly mobile and stationary phases). (C) 2015 Elsevier B.V. All rights reserved.
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