Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 74, Issue -, Pages 120-129Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2015.03.027
Keywords
Aptamer; Biosensor; Fluorescence; Functional nucleic acid; Graphene material; Graphene oxide; Nucleic-acid manipulation; Probe amplification; Signal amplification; Target amplification
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Ministry of Research and Innovation, Ontario
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Integrating functional DNA probes with graphene oxide (GO) has proved to be a productive approach to the design of optical biosensors that detect nucleic acids, proteins or small-molecule targets. This distinctive methodology neatly combines four intriguing properties associated with DNA and GO: the functional versatility of DNA sequences as molecular receptors; the ability of DNA to switch structural forms in a target-responsive manner; the power of GO as a fluorescence quencher; and, the differential affinity of GO for different structural forms of DNA. In recent years, several elegant signal-amplification strategies uniquely applicable to optical DNA-GO biosensors were reported and these amplified biosensors were productively employed to achieve ultrasensitive detection of diverse targets. This review highlights notable achievements in this budding research field and provides a perspective on where the field is heading. (C) 2015 Elsevier B.V. All rights reserved.
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