Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 67, Issue -, Pages 128-133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2015.01.009
Keywords
Biphasic chiral recognition; Chiral chromatography; Chiral selector; Chiral separation; Counter-current chromatography; Liquid-liquid partition; Multiple dual-mode elution; Recycling elution mode; Separation efficiency; Solvent system
Categories
Funding
- National Natural Science Foundation of China (NSFC) [20775083, 21175142]
- CAS
Ask authors/readers for more resources
Counter-current chromatography (CCC) is a new, efficient, productive chromatographic technique based on continuous liquid-liquid partition. Recently, it attracted more attention in chiral separation due to its high load capacity, cheap liquid stationary phase and low solvent consumption, when compared to traditional chiral separation techniques. This review presents advances and applications of chiral separation using high-speed CCC in recent years. We summarize the major benefits and the limitations of chiral separation by CCC. We introduce in detail some novel methods, which can improve the resolution of enantiomers and are easily achieved on classical CCC apparatus. We also outline challenges and future perspectives in developing chiral separation by CCC. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available