A Theoretical and Experimental Analysis of Radiofrequency Ablation with a Multielectrode, Phased, Duty-Cycled System

Methods: The computational model for each of the five operating modes offered by the generator is compared to independent tissue temperature measurements taken during in vitro ablation experiments performed on bovine myocardium. Results: The results of the model agree with experimental temperature measurements very closely-the average values for mean error, root mean square difference, and correlation coefficient were 1.9 degrees C, 13.3%, and 0.97, respectively. Lesions are shown to be contiguous and no significant edge effects are observed. Conclusions: Both the in vitro and computational model results demonstrate that lesion depth decreases consistently as the bipolar-to-unipolar ratio increases-suggesting a clinical application to potentially control lesion depth with higher fidelity than is currently available. The effect of variable design parameters and clinical conditions on RF ablation can now be expeditiously studied with this validated model. (PACE 2010; 33:1089-1100).