Journal
OZONE-SCIENCE & ENGINEERING
Volume 35, Issue 3, Pages 186-195Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01919512.2013.771530
Keywords
Ozone; Kinetics; Ofloxacin; Pharmaceuticals; Water Treatment
Categories
Funding
- Spanish Ministry of Education
- FEDER funds of the European Union [CTQ2009-13459-C05-05]
- Consejeria de Empleo, Empresa e Innovacion of the Gobierno de Extremadura
- FEDER funds
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The ozonation of the quinolone antibiotic ofloxacin in water has been investigated with focus on kinetic parameters determination. The apparent stoichiometric factor and the second-order rate constants of the reactions of ozone and hydroxyl radical with ofloxacin were determined at 20 degrees C in the pH range of 49. The apparent stoichiometric factor was found to be about 2.5 mol O-3/mol ofloxacin regardless of the pH. The rate constant of the reaction between ozone and ofloxacin was determined by a competitive method (pH = 69) and a direct ozonation method (pH = 4). It was found that this rate constant increases with pH due to the dissociation of ofloxacin in water. The direct rate constants of ofloxacin species were determined to be 1.0x10(2), 4.3x10(4) and 3.7x10(7) for cationic, neutral-zwitterion and anionic species, respectively. Accordingly, the attack of ozone to ofloxacin mainly takes place at the tertiary amine group of the piperazine ring, though some reactivity is also due to the quinolone structure and oxazine substituent. The rate constant of the reaction between ofloxacin and hydroxyl radical was obtained from UV/H2O2 photodegradation experiments. It was found that this rate constant varies with pH from 3.2x10(9) at pH 4 to 5.1x10(9) at pH 9.
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