Journal
TOXICOLOGY LETTERS
Volume 232, Issue 2, Pages 475-480Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2014.12.001
Keywords
Air pollution; Decidua; Inflammation; Placenta and pregnancy
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo State Research Foundation) [2011/05973-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/05973-1] Funding Source: FAPESP
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This study aimed to verify the development of placental and systemic inflammation in rats exposed to fine particulate matter before or during pregnancy. Wistar rats were exposed to filtered air ( control) or to a load of 600 mu g/m(3) of fine particles in the air. The gene expression of IL-1 beta, IL-4, IL-6, IL-10, INF-gamma, TNF-alpha and Toll-like receptor 4 in the placenta was evaluated. The serum and placental concentrations of IL-1 beta, IL-4, IL-6, IL-10, INF-gamma and TNF-alpha were measured. The total and differential blood leukocyte and blood platelet count was assessed. Compared to control animals, IL-4 content was elevated in the fetal portion of the placenta in rats exposed to air pollution before and during pregnancy. Increased IL-4 suggests that a placental inflammatory reaction may have occurred in response to exposure to fine particulate matter and that this cytokine was responsible, among possibly others factors, for resolution of the inflammatory reaction. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
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