Journal
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Volume 148, Issue 3, Pages 366-373Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0194599812470427
Keywords
rhinitis; sinusitis; macrolide; chronic rhinosinusitis; chronic sinusitis; human; adult; meta-analysis
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Funding
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1RR0249864]
- National Center for Research Resources
- National Center for Advancing Translational Sciences, National Institutes of Health [KL2 RR025015]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR000421] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [KL2RR025015, UL1RR025014] Funding Source: NIH RePORTER
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Objective. The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis. Data Sources. EMBASE and PubMed databases were searched in October 2011. Review Methods. A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review. Results. This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis. Conclusion. Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.
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