Journal
TOXICOLOGY LETTERS
Volume 237, Issue 3, Pages 167-173Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2015.06.001
Keywords
Particulate matter; Metalloproteases; Invasiveness; E-cadherin; beta-catenin
Categories
Funding
- CONACyT-Mexico [43183-M, AC-2006-52830]
Ask authors/readers for more resources
Airborne particulate matter with an aerodynamic diameter <= 10 mu m (PM10) is a risk factor for the development of lung diseases and cancer. The aim of this work was to identify alterations in airway epithelial (A549) cells induced by PM10 that could explain how subtoxic exposure (10 mu g/cm(2)) promotes a more aggressive in vitro phenotype. Our results showed that cells exposed to PM10 from an industrial zone (IZ) and an urban commercial zone (CZ) induced an increase in protease activity and invasiveness; however, the cell mechanism is different, as only PM10 from CZ up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/beta-catenin expression after 48 h of exposure. These in vitro findings are relevant in terms of the mechanism action of PM10 in lung epithelial cells, which could be helpful in understanding the pathogenesis of some human illness associated with highly polluted cities. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available