Recurrent Respiratory Papillomatosis

Recurrent respiratory papillomatosis (RAP) is a rare, benign disease with no known cure. RAP is caused by infection of the upper aerodigestive tract with the human papillomavirus (HPV). Passage through the birth canal is thought to be the initial transmission event, but infection may occur in utero. HPV vaccines have helped to provide protection from cervical cancer; however, their role in the prevention of RAP is undetermined. Clinical presentation of initial symptoms of RAP may be subtle. RAP course varies, and current management focuses on surgical debulking of papillomatous lesions with or without concurrent adjuvant therapy.