Journal
OSTEOPOROSIS INTERNATIONAL
Volume 21, Issue 9, Pages 1617-1619Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s00198-009-1123-7
Keywords
Bisphosphonates; Osteoarthritis; Side effects; Zoledronic acid
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Zoledronic acid is effective for osteoporosis at a single annual intravenous dose. It usually causes few adverse effects; the most common are related to acute phase reactions. We reported the case of a 64-year-old woman who presented flare-up of hand osteoarthritis after zoledronic acid infusions. Despite the fact that arthralgia is a common side effect of intravenous bisphosphonates, development of inflammatory signs in osteoarthritic joints is a rare event. We hypothesized that this side effect is caused by a release of cytokines secondary to activation of gamma-delta T lymphocytes.
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