Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 22, Issue 8, Pages 1120-1128Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2014.06.007
Keywords
Osteoarthritis; Osteoporosis; DXA; Radiology; Epidemiology
Categories
Funding
- Wellcome Trust [080280/Z/06/Z]
- NIHR CRN [5163]
- Arthritis Research UK [19580, 20000]
- MRC
- Arthritis Research UK
- NIHR Nutrition Biomedical Research Centre, University of Southampton
- MRC [MC_UU_12013/1] Funding Source: UKRI
- Cancer Research UK
- Versus Arthritis [20000] Funding Source: researchfish
- Medical Research Council [MC_UP_A620_1014, MC_UU_12013/1, MC_UU_12011/1, U1475000001] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, ACF-2012-13-014, CL-2006-18-006, NF-SI-0508-10082] Funding Source: researchfish
- Versus Arthritis [19580] Funding Source: researchfish
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Objective: Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) have a higher prevalence of radiographic hip OA compared with controls. Design: HBM cases came from the UK-based HBM study: HBM was defined by BMD Z-score. Unaffected relatives of index cases were recruited as family controls. Age-stratified random sampling was used to select further population controls from the Chingford and Hertfordshire cohort studies. Pelvic radiographs were pooled and assessed by a single observer blinded to case-control status. Analyses used logistic regression, adjusted for age, gender and body mass index (BMI). Results: 530 HBM hips in 272 cases (mean age 62.9 years, 74% female) and 1702 control hips in 863 controls (mean age 64.8 years, 84% female) were analysed. The prevalence of radiographic OA, defined as Croft score >= 3, was higher in cases compared with controls (20.0% vs 13.6%), with adjusted odds ratio (OR) [95% CI] 1.52 [1.09, 2.11], P = 0.013. Osteophytes (OR 2.12 [1.61, 2.79], P < 0.001) and subchondral sclerosis (OR 2.78 [1.49, 5.18], P = 0.001) were more prevalent in cases. However, no difference in the prevalence of joint space narrowing (JSN) was seen (OR 0.97 [0.72, 1.33], P = 0.869). Conclusions: An increased prevalence of radiographic hip OA and osteophytosis was observed in HBM cases compared with controls, in keeping with a positive association between HBM and OA and suggesting that OA in HBM has a hypertrophic phenotype. (C) 2014 The Authors. Published by Elsevier Ltd and Osteoarthritis Research Society International.
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