Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 22, Issue 10, Pages 1675-1691Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2014.06.020
Keywords
Knee osteoarthritis; Musculoskeletal ultrasound; Clinical outcome; KOOS; Kellgrene-Lawrence score
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Funding
- Oak Foundation
- Velux Foundation
- Cambridge Health and Weight plan UK
- Danish Rheumatism Association
- Augustinus Foundation
- A.P. Moller Foundation for the Advancement of Medical Science
- Horslev Fonden
- Bjarne Jensens Fond
- Aase og Ejnar Danielsens fond
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Objective: To develop standardized musculoskeletal ultrasound (MUS) procedures and scoring for detecting knee osteoarthritis (OA) and test the MUS score's ability to discern various degrees of knee OA, in comparison with plain radiography and the 'Knee injury and Osteoarthritis Outcome Score' (KOOS) domains as comparators. Method: A cross-sectional study of MUS examinations in 45 patients with knee OA. Validity, reliability, and reproducibility were evaluated. Results: MUS examination for knee OA consists of five separate domains assessing (1) predominantly morphological changes in the medial compartment, (2) predominantly inflammation in the medial compartment, (3) predominantly morphological changes in the lateral compartment, (4) predominantly inflammation in the lateral compartment, and (5) effusion. MUS scores displayed substantial reliability and reproducibility, with interclass correlations coefficients ranging from 0.75 to 0.97 for the five domains. Construct validity was confirmed with statistically significant correlation coefficients (0.47-0.81, P < 0.01). Conclusion: The MUS score suggested in this study was reliable and valid in detecting knee OA. In comparison with standing radiographs of the knees, the score detected all aspects of knee OA with relevant precision. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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