Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 18, Issue -, Pages S1-S6Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2010.02.017
Keywords
Chondroitin sulfate; Inflammation; Immune diseases; Oateoarthritis; Psoriasis; Inflammatory bowel diseases; Atherosclerosis; Parkinson's and Alzheimer's diseases; Review
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Objective and methods: To evaluate the immune-modulator effect of chondroitin sulfate (CS) by means of the review of the literature. Results: Inflammatory reactions are primarily originated by infectious agents, immune reactions and by sterile tissue lesions that activate membrane receptors by means of pathogen-associated molecular patterns, tissue breakdown products and cytokines. The activation of membrane receptors triggers the phosphorylation of mitogen activated protein kinases and of the nuclear factor kappa B (NF-kappa B). The binding of NF-kappa B to the promoter of target genes enhances the expression of pro-inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase 2, phospholipase A2, and matrix metalloproteases, proteins that contribute to tissue damage and to the inflammatory reaction. The activation of NF-kappa B has a key role in the immune homeostasis and the inflammatory response and therefore, in the pathogenesis of numerous diseases. Chondroitin sulfate (CS) is able to diminish NF-kappa B activation and nuclear translocation in chondrocytes and synovial membrane, effects that may explain the benefits of CS in osteoarthritis. In addition, systemic CS reduces NF-kappa B nuclear translocation in macrophages and hepatocytes, raising the hypothesis that CS might be of benefit to treat other diseases with a strong inflammatory component. There is preliminary evidence in humans that CS improves moderate to severe psoriasis. Moreover, experimental and clinical data suggest that CS might be a useful therapeutic agent in diseases such as inflammatory bowel diseases, atherosclerosis, Parkinson's and Alzheimer's diseases, multiple sclerosis, amyotrophic lateral sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Discussion: These results urge for double blinded placebo-controlled trials to confirm the utility of CS in diseases with immune and inflammatory components. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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