Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 16, Issue 5, Pages 584-590Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2007.10.019
Keywords
magnetic resonance imaging; osteoarthritis; cartilage T-2; texture analysis; GLCM
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Funding
- NIAMS NIH HHS [R01 AR046905-07, R01 AR046905] Funding Source: Medline
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Objective: The purpose of this study was (1) to characterize the spatial distribution of cartilage T-2 in postmenopausal osteoarthritis (OA) patients and age-matched healthy subjects using second order texture measures at baseline, and (2) to analyze changes in the texture of cartilage T-2 after 9 months. Methods: 3.0 T-MRI of the knee was performed in 8 mild OA patients and 10 age-matched controls at baseline and after 9 months. Cartilage T-2, volume, and average thickness were calculated in all patients. Texture analysis, based on the gray level co-occurrence matrix, was performed on the cartilage T-2 maps. Texture parameters, including entropy and angular second moment, were calculated at 0 degrees (corresponding to the anterior-posterior axis) and at 90 degrees (corresponding to the superior-inferior axis), with pixel offsets ranging from 1 to 3 pixels. Results: Least square means analysis showed that mean T-2 values, their standard deviation (SD), and their entropy were greater (P < 0.05) in CA patients than in controls. Over 9 months, the SD and entropy of cartilage T-2 significantly (P < 0.05) decreased in OA patients, while no significant changes were evident in cartilage thickness or volume. Conclusion: The mean cartilage T-2 values, their SD, and their entropy were greater in CA patients than in controls, indicating that the T-2 values in osteoarthritic cartilage are not only elevated, but also more heterogeneous than those in healthy cartilage. The longitudinal results demonstrate that changes in texture parameters of cartilage T-2 may precede morphological changes in thickness and volume in the progression of OA. (C) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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